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recombinant mouse ip-10 (cxcl10  (PeproTech)

 
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    PeproTech recombinant mouse ip-10 (cxcl10
    FMNL1 mediates T cell migration independently of Myosin-II. WT, FMNL1 KO, and mDia1 KO T cells were collected from donor mice, ex vivo activated, and differentially fluorescently labeled. (A) T cells were seeded onto 3μm transwell inserts with 50μM Blebbistatin or a vehicle control and 100 ng/mL <t>CXCL10</t> in the bottom well. Percent migration is calculated as the number of cells counted in the bottom well normalized to a 20% loading control well. (B–F) T cells were embedded in 1.0 mg/mL collagen with increasing concentrations of para-nitro-Blebbistatin. (B) Representative maximum Z-projection images of WT (red) FMNL1 KO (green), and mDia1 KO (cyan) T cell migration through 1.0 mg/mL collagen matrices treated with either DMSO (top) or 10 μM para-nitro-Blebbistatin (bottom). Track lines show the path taken by the cells over 25 min. (C) Trajectory plots of the DMSO and 10 μM Blebbistatin-treated groups for all cells analyzed in (D–F) . (D–F) Quantification of mean track speed, average arrest coefficient, and mean squared displacement of cells tracked continuously for 10 min. Cells were treated with a DMSO control, 3 μM or 10 μM para-nitro-Blebbistatin. Data in (A) represents the mean +/- SEM of three independent experiments. Significance was determined by One-way ANOVA. Data in (D–F) represent the mean +/- SEM of at least 165 cells per condition pooled from three independent experiments. Significance was determined by Brown-Forsythe and Welch ANOVA tests with Games-Howell’s multiple comparisons test. ns, not significant, * = p<0.05, ** = p<0.01, *** = p<0.001, **** = p<0.0001.
    Recombinant Mouse Ip 10 (Cxcl10, supplied by PeproTech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/recombinant mouse ip-10 (cxcl10/product/PeproTech
    Average 90 stars, based on 1 article reviews
    recombinant mouse ip-10 (cxcl10 - by Bioz Stars, 2026-03
    90/100 stars

    Images

    1) Product Images from "FMNL1 and mDia1 promote efficient T cell migration through complex environments via distinct mechanisms"

    Article Title: FMNL1 and mDia1 promote efficient T cell migration through complex environments via distinct mechanisms

    Journal: Frontiers in Immunology

    doi: 10.3389/fimmu.2024.1467415

    FMNL1 mediates T cell migration independently of Myosin-II. WT, FMNL1 KO, and mDia1 KO T cells were collected from donor mice, ex vivo activated, and differentially fluorescently labeled. (A) T cells were seeded onto 3μm transwell inserts with 50μM Blebbistatin or a vehicle control and 100 ng/mL CXCL10 in the bottom well. Percent migration is calculated as the number of cells counted in the bottom well normalized to a 20% loading control well. (B–F) T cells were embedded in 1.0 mg/mL collagen with increasing concentrations of para-nitro-Blebbistatin. (B) Representative maximum Z-projection images of WT (red) FMNL1 KO (green), and mDia1 KO (cyan) T cell migration through 1.0 mg/mL collagen matrices treated with either DMSO (top) or 10 μM para-nitro-Blebbistatin (bottom). Track lines show the path taken by the cells over 25 min. (C) Trajectory plots of the DMSO and 10 μM Blebbistatin-treated groups for all cells analyzed in (D–F) . (D–F) Quantification of mean track speed, average arrest coefficient, and mean squared displacement of cells tracked continuously for 10 min. Cells were treated with a DMSO control, 3 μM or 10 μM para-nitro-Blebbistatin. Data in (A) represents the mean +/- SEM of three independent experiments. Significance was determined by One-way ANOVA. Data in (D–F) represent the mean +/- SEM of at least 165 cells per condition pooled from three independent experiments. Significance was determined by Brown-Forsythe and Welch ANOVA tests with Games-Howell’s multiple comparisons test. ns, not significant, * = p<0.05, ** = p<0.01, *** = p<0.001, **** = p<0.0001.
    Figure Legend Snippet: FMNL1 mediates T cell migration independently of Myosin-II. WT, FMNL1 KO, and mDia1 KO T cells were collected from donor mice, ex vivo activated, and differentially fluorescently labeled. (A) T cells were seeded onto 3μm transwell inserts with 50μM Blebbistatin or a vehicle control and 100 ng/mL CXCL10 in the bottom well. Percent migration is calculated as the number of cells counted in the bottom well normalized to a 20% loading control well. (B–F) T cells were embedded in 1.0 mg/mL collagen with increasing concentrations of para-nitro-Blebbistatin. (B) Representative maximum Z-projection images of WT (red) FMNL1 KO (green), and mDia1 KO (cyan) T cell migration through 1.0 mg/mL collagen matrices treated with either DMSO (top) or 10 μM para-nitro-Blebbistatin (bottom). Track lines show the path taken by the cells over 25 min. (C) Trajectory plots of the DMSO and 10 μM Blebbistatin-treated groups for all cells analyzed in (D–F) . (D–F) Quantification of mean track speed, average arrest coefficient, and mean squared displacement of cells tracked continuously for 10 min. Cells were treated with a DMSO control, 3 μM or 10 μM para-nitro-Blebbistatin. Data in (A) represents the mean +/- SEM of three independent experiments. Significance was determined by One-way ANOVA. Data in (D–F) represent the mean +/- SEM of at least 165 cells per condition pooled from three independent experiments. Significance was determined by Brown-Forsythe and Welch ANOVA tests with Games-Howell’s multiple comparisons test. ns, not significant, * = p<0.05, ** = p<0.01, *** = p<0.001, **** = p<0.0001.

    Techniques Used: Migration, Ex Vivo, Labeling, Control

    Key resources.
    Figure Legend Snippet: Key resources.

    Techniques Used: Recombinant, Fractionation, Cell Culture



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    FMNL1 mediates T cell migration independently of Myosin-II. WT, FMNL1 KO, and mDia1 KO T cells were collected from donor mice, ex vivo activated, and differentially fluorescently labeled. (A) T cells were seeded onto 3μm transwell inserts with 50μM Blebbistatin or a vehicle control and 100 ng/mL <t>CXCL10</t> in the bottom well. Percent migration is calculated as the number of cells counted in the bottom well normalized to a 20% loading control well. (B–F) T cells were embedded in 1.0 mg/mL collagen with increasing concentrations of para-nitro-Blebbistatin. (B) Representative maximum Z-projection images of WT (red) FMNL1 KO (green), and mDia1 KO (cyan) T cell migration through 1.0 mg/mL collagen matrices treated with either DMSO (top) or 10 μM para-nitro-Blebbistatin (bottom). Track lines show the path taken by the cells over 25 min. (C) Trajectory plots of the DMSO and 10 μM Blebbistatin-treated groups for all cells analyzed in (D–F) . (D–F) Quantification of mean track speed, average arrest coefficient, and mean squared displacement of cells tracked continuously for 10 min. Cells were treated with a DMSO control, 3 μM or 10 μM para-nitro-Blebbistatin. Data in (A) represents the mean +/- SEM of three independent experiments. Significance was determined by One-way ANOVA. Data in (D–F) represent the mean +/- SEM of at least 165 cells per condition pooled from three independent experiments. Significance was determined by Brown-Forsythe and Welch ANOVA tests with Games-Howell’s multiple comparisons test. ns, not significant, * = p<0.05, ** = p<0.01, *** = p<0.001, **** = p<0.0001.
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    Image Search Results


    FMNL1 mediates T cell migration independently of Myosin-II. WT, FMNL1 KO, and mDia1 KO T cells were collected from donor mice, ex vivo activated, and differentially fluorescently labeled. (A) T cells were seeded onto 3μm transwell inserts with 50μM Blebbistatin or a vehicle control and 100 ng/mL CXCL10 in the bottom well. Percent migration is calculated as the number of cells counted in the bottom well normalized to a 20% loading control well. (B–F) T cells were embedded in 1.0 mg/mL collagen with increasing concentrations of para-nitro-Blebbistatin. (B) Representative maximum Z-projection images of WT (red) FMNL1 KO (green), and mDia1 KO (cyan) T cell migration through 1.0 mg/mL collagen matrices treated with either DMSO (top) or 10 μM para-nitro-Blebbistatin (bottom). Track lines show the path taken by the cells over 25 min. (C) Trajectory plots of the DMSO and 10 μM Blebbistatin-treated groups for all cells analyzed in (D–F) . (D–F) Quantification of mean track speed, average arrest coefficient, and mean squared displacement of cells tracked continuously for 10 min. Cells were treated with a DMSO control, 3 μM or 10 μM para-nitro-Blebbistatin. Data in (A) represents the mean +/- SEM of three independent experiments. Significance was determined by One-way ANOVA. Data in (D–F) represent the mean +/- SEM of at least 165 cells per condition pooled from three independent experiments. Significance was determined by Brown-Forsythe and Welch ANOVA tests with Games-Howell’s multiple comparisons test. ns, not significant, * = p<0.05, ** = p<0.01, *** = p<0.001, **** = p<0.0001.

    Journal: Frontiers in Immunology

    Article Title: FMNL1 and mDia1 promote efficient T cell migration through complex environments via distinct mechanisms

    doi: 10.3389/fimmu.2024.1467415

    Figure Lengend Snippet: FMNL1 mediates T cell migration independently of Myosin-II. WT, FMNL1 KO, and mDia1 KO T cells were collected from donor mice, ex vivo activated, and differentially fluorescently labeled. (A) T cells were seeded onto 3μm transwell inserts with 50μM Blebbistatin or a vehicle control and 100 ng/mL CXCL10 in the bottom well. Percent migration is calculated as the number of cells counted in the bottom well normalized to a 20% loading control well. (B–F) T cells were embedded in 1.0 mg/mL collagen with increasing concentrations of para-nitro-Blebbistatin. (B) Representative maximum Z-projection images of WT (red) FMNL1 KO (green), and mDia1 KO (cyan) T cell migration through 1.0 mg/mL collagen matrices treated with either DMSO (top) or 10 μM para-nitro-Blebbistatin (bottom). Track lines show the path taken by the cells over 25 min. (C) Trajectory plots of the DMSO and 10 μM Blebbistatin-treated groups for all cells analyzed in (D–F) . (D–F) Quantification of mean track speed, average arrest coefficient, and mean squared displacement of cells tracked continuously for 10 min. Cells were treated with a DMSO control, 3 μM or 10 μM para-nitro-Blebbistatin. Data in (A) represents the mean +/- SEM of three independent experiments. Significance was determined by One-way ANOVA. Data in (D–F) represent the mean +/- SEM of at least 165 cells per condition pooled from three independent experiments. Significance was determined by Brown-Forsythe and Welch ANOVA tests with Games-Howell’s multiple comparisons test. ns, not significant, * = p<0.05, ** = p<0.01, *** = p<0.001, **** = p<0.0001.

    Article Snippet: Recombinant Mouse IP-10 (CXCL10) , Peprotech , 250-16.

    Techniques: Migration, Ex Vivo, Labeling, Control

    Key resources.

    Journal: Frontiers in Immunology

    Article Title: FMNL1 and mDia1 promote efficient T cell migration through complex environments via distinct mechanisms

    doi: 10.3389/fimmu.2024.1467415

    Figure Lengend Snippet: Key resources.

    Article Snippet: Recombinant Mouse IP-10 (CXCL10) , Peprotech , 250-16.

    Techniques: Recombinant, Fractionation, Cell Culture

    Upregulation of Cxcl10 in inflamed ears of CHS mice. a Representative photographs of mouse ears challenged with vehicle (Control) or DNFB (Inflamed). Photos were taken 24 h after challenging. b Thickness of mice ears challenged with vehicle (Control) or DNFB (Inflamed) before (Pre), 24 h and 72 h after challenging (n = 3–4 per group). c mRNA expression of Cxcl10 transcript in mouse ears challenged with vehicle (Control) or DNFB (Inflamed) (n = 3 per group). *** P < 0.001; ns, no significance; error bars, SEM

    Journal: Journal of Nanobiotechnology

    Article Title: Unveiling the improved targeting migration of mesenchymal stem cells with CXC chemokine receptor 3-modification using intravital NIR-II photoacoustic imaging

    doi: 10.1186/s12951-022-01513-7

    Figure Lengend Snippet: Upregulation of Cxcl10 in inflamed ears of CHS mice. a Representative photographs of mouse ears challenged with vehicle (Control) or DNFB (Inflamed). Photos were taken 24 h after challenging. b Thickness of mice ears challenged with vehicle (Control) or DNFB (Inflamed) before (Pre), 24 h and 72 h after challenging (n = 3–4 per group). c mRNA expression of Cxcl10 transcript in mouse ears challenged with vehicle (Control) or DNFB (Inflamed) (n = 3 per group). *** P < 0.001; ns, no significance; error bars, SEM

    Article Snippet: Rabbit polyclonal antibody against Cxcr3 (NB100-56404), recombinant Cxcl10 protein (466-CR) were purchased from R&D systems (Minneapolis, MN, USA).

    Techniques: Control, Expressing

    Overexpression of Cxcr3 in MSCs. a Representative bright field (BF) and green fluorescence images of MSC eGFP and MSC Cxcr3 . MSCs were transduced with lentivirus to express eGFP alone (MSC eGFP ) or in combination with Cxcr3 (MSC Cxcr3 ). b Analysis of Cxcr3 mRNA expression in MSC eGFP and MSC Cxcr3 . c Western blot of Cxcr3 in total cell lysates of MSC eGFP and MSC Cxcr3 . CypB, cyclophilin B, used as housekeeping gene. d Cxcr3 overexpression promoted the in vitro migration of MSCs toward Cxcl10. Representative images and quantification analysis of transwell migration assay were shown. e Quantification analysis of transwell migration assay of MSC Cxcr3 after incubating with vehicle (PBS) or TAT-CPNPs (NPs). Scale bars, 100 µm. * P < 0.05, *** P < 0.001; error bars, SEM

    Journal: Journal of Nanobiotechnology

    Article Title: Unveiling the improved targeting migration of mesenchymal stem cells with CXC chemokine receptor 3-modification using intravital NIR-II photoacoustic imaging

    doi: 10.1186/s12951-022-01513-7

    Figure Lengend Snippet: Overexpression of Cxcr3 in MSCs. a Representative bright field (BF) and green fluorescence images of MSC eGFP and MSC Cxcr3 . MSCs were transduced with lentivirus to express eGFP alone (MSC eGFP ) or in combination with Cxcr3 (MSC Cxcr3 ). b Analysis of Cxcr3 mRNA expression in MSC eGFP and MSC Cxcr3 . c Western blot of Cxcr3 in total cell lysates of MSC eGFP and MSC Cxcr3 . CypB, cyclophilin B, used as housekeeping gene. d Cxcr3 overexpression promoted the in vitro migration of MSCs toward Cxcl10. Representative images and quantification analysis of transwell migration assay were shown. e Quantification analysis of transwell migration assay of MSC Cxcr3 after incubating with vehicle (PBS) or TAT-CPNPs (NPs). Scale bars, 100 µm. * P < 0.05, *** P < 0.001; error bars, SEM

    Article Snippet: Rabbit polyclonal antibody against Cxcr3 (NB100-56404), recombinant Cxcl10 protein (466-CR) were purchased from R&D systems (Minneapolis, MN, USA).

    Techniques: Over Expression, Fluorescence, Transduction, Expressing, Western Blot, In Vitro, Migration, Transwell Migration Assay